Sermorelin
Mechanism
A GHRH analog, just the first 29 residues of the real thing, and that is apparently all your pituitary needs to hear. It releases its own growth hormone, on its own feedback loop, the way it was always designed to.
Key Benefit
Improves body composition, sleep quality, and skin elasticity. Original FDA approval was for GH deficiency diagnostics; clinical use expanded.
Evidence Base
This one was FDA-approved once. Geref, 1997, strictly for diagnosing GH deficiency. It got pulled for money reasons, not safety, and that distinction matters. Compounding pharmacies never stopped making it.
Route & Rationale
Subcutaneous injection (daily, at bedtime). Peptide requires SC delivery. Bedtime dosing matches nocturnal GH pulse physiology.
Interactions
Monitor IGF-1. May interact with glucocorticoids (blunt GH response).
Regulatory Status
Previously FDA-approved, pulled from the market for business reasons, nothing about safety. You can still get it through compounding pharmacies. WADA has it flagged as a GH secretagogue, banned same as the rest of that family.
Hard Contraindications
Cancer (active/history), Pregnancy/planning
For information and research purposes only. This is not medical advice and not a recommendation to use this substance. Discuss anything here with your healthcare provider.
